<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6034 6034-30423 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54T, V82A   L10I, K20R, E34Q, E35D, M36I, N37D, R57K, D60DE, Q61QHKN, L63AP, A71I, I72V, I93L  
>6034-30423| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLQDIDLPGRWKPKMIVGIGGFTKVKQYE
NIPIEICGHKIVGTVLVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184I, L210W, T215Y K219R Y188L   E44D, K101KQ, K102KQ, V118I, K122KE, D123X, V179I, T200TA, E203EK, H208Y, R211K, K223Q, V245K, D250E, S251H, V292I, I293V, S322T, G359S, A371V, K390R Q269H, R284S
>6034-30423| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQQKKSVTVLDVGDAYFSIPL
DEXFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
YQYIDDLLVGSDLEIGQHRAKIKELRQYLWKWGFYTPDRKHQQEPPFLWMGYELHPDKWT
VQPIKLPEKEHWTVNDIQKLVGKLNWASHIYAGIKVKQLCKLLSGTKALTEIVPLTEEAE
LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006