Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6033 | 6033-30423 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219R | K101E, Y181C, G190A | V108I | K20R, V35M, T39A, K43KE, E44D, V118I, K166R, R172K, G196E, T200A, R211K, H221Y, V245VI, A272P, K277R, A288S, I293V, E297A, Q334HN, Y342F, R356K, A360T, K366R, T369V, E370ED, A371T, S379C | N54NI |
| >6033-30423| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEEDGKISKIGPEIPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFKKQNPDIVI CQYMDDLYVASDLEIEQHRAKIEELRQHLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT VQPIILPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNGQWTYQIFQEPFKNLKTGKYAKMRGT HTNDVRQLVDTVQKIATECIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54S, V82A | L10I, K20R, M36I, N37D, I62V, L63PQ, A71V, I93L |
| >6033-30423| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEIDLPGRWKPKLIVGIGGFSKVRQYD QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |