<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6033 6033-30423 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48V, I54S, V82A   L10I, K20R, M36I, N37D, I62V, L63PQ, A71V, I93L  
>6033-30423| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEIDLPGRWKPKLIVGIGGFSKVRQYD
QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y K219R K101E, Y181C, G190A V108I K20R, V35M, T39A, K43KE, E44D, V118I, K166R, R172K, G196E, T200A, R211K, H221Y, V245VI, A272P, K277R, A288S, I293V, E297A, Q334HN, Y342F, R356K, A360T, K366R, T369V, E370ED, A371T, S379C N54NI
>6033-30423| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEEDGKISKIGPEIPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFKKQNPDIVI
CQYMDDLYVASDLEIEQHRAKIEELRQHLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT
VQPIILPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNGQWTYQIFQEPFKNLKTGKYAKMRGT
HTNDVRQLVDTVQKIATECIVIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006