Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6029 | 6029-30410 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L33F, F53L, G73T | L10I, I13V, I15V, K20R, M36I, R41K, L63P, A71V |
| >6029-30410| codons 1-99 PQITLWQRPIVTVKVGGQLREALLDTGADDTIFEEINLPGKWKPKIVGGIGGLLKVRQYD QIPIEICGHKVITTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215F | K219R | V106A, G190A | V108I, F227L | V35I, E40F, K43E, W88C, L109I, V118I, K122E, I135V, D177E, G196E, T200A, H208Y, R211K, K223E, E224K, L228R, D237E, P243T, A272P, K275R, L283I, I293V, E297K, Q330QH, K350R, R356RK, G359S, D364E, A371V, I375V, A376V, S379C, T386A, K390R |
| >6029-30410| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSDKWRKLMDFRELNKRTQDFCEVQLGIPHPAGLKKKKSATIIDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVASDLEIEQHRAKIEELRQYLWKWGFFTPDRKHQEKPPLRWMGYELHPEKWT VQTIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLIRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIHKQGQGQWTYQIYQEPFKNLRTGKYAKMRSA HTNEVKQLTEVVQKVVTECIVIWGKAPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |