Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6028 | 6028-30409 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K103N, Y181C, G190GA | A98G, V108VI | K20R, K43KN, E44D, T69TA, K102KR, V118VI, K122KE, D123EK, I142V, E203EK, H208F, R211K, K223KT, V245E, D250E, A272P, K281KR, T286A, A288S, E297K, M357T, A376AV, T377LS, S379AG, T386I | G273GE |
| >6028-30409| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSAKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKRNKSVTILDVGDAYFSIPL DEKFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIKELRQFLWKWGFYTPDKKHQTEPPFLWMGYELHPDKWT VQPIELPEKESWTVNDIQKLVGKLNWASQIYPEIKVKQLCRLLRGAKSLTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIVSEGIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82F, L90M | V11VI, L33LF, F53L | L10V, I13IV, R41K, K45V, I62V, L63P, H69K, A71V, I72V, T74A, V77I |
| >6028-30409| codons 1-99 PQITLWQRPVITVKIGGQLKEALLDTGADDTVFEEMNLPGKWKPVMIGGIGGLVKVRQYD QVPIEICGKKVVGAVLIGPTPFNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |