<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6028 6028-30409 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y   K103N, Y181C, G190GA A98G, V108VI K20R, K43KN, E44D, T69TA, K102KR, V118VI, K122KE, D123EK, I142V, E203EK, H208F, R211K, K223KT, V245E, D250E, A272P, K281KR, T286A, A288S, E297K, M357T, A376AV, T377LS, S379AG, T386I G273GE
>6028-30409| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV
FAIKKKNSAKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKRNKSVTILDVGDAYFSIPL
DEKFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYVDDLYVASDLEIGQHRTKIKELRQFLWKWGFYTPDKKHQTEPPFLWMGYELHPDKWT
VQPIELPEKESWTVNDIQKLVGKLNWASQIYPEIKVKQLCRLLRGAKSLTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKIVSEGIVIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82F, L90M V11VI, L33LF, F53L L10V, I13IV, R41K, K45V, I62V, L63P, H69K, A71V, I72V, T74A, V77I  
>6028-30409| codons 1-99
PQITLWQRPVITVKIGGQLKEALLDTGADDTVFEEMNLPGKWKPVMIGGIGGLVKVRQYD
QVPIEICGKKVVGAVLIGPTPFNIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006