Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6027 | 6027-30409 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | V11I, G73S | L10I, I13V, I15V, G16A, K20IV, M36I, R41K, L63P, A71V, I72L, I85V |
| >6027-30409| codons 1-99 PQITLWQRPIITVKVAGQLVEALLDTGADDTVLEEINLPGKWKPKIVGGIGGFMKVRQYD QIPIEICGHKVLSTVLVGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, D67N, Q151M, M184I, T215Y | A62V, V75I, F116Y, K219E | Y181C, G190A | K101NS, V108I | I31R, K49R, S68K, V90I, K122E, S162D, R172K, V189VI, I202V, A272P, V276T, Q278E, E297A, E298A, M357T, R358K, T369A, A376N, T386S, K390KR | I309IS |
| >6027-30409| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKRKALVEICTELEKEGKISRIGPENPYNTPV FVIKRKNKTKWRKLIDFRELNKRTQDFWEIQLGIPHPAGLSKKKSVTILDVGDAYYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQDSMTKILEPFKKQNPDIVI CQYIDDLYIASDLEIGQHRTKVEELRQHLLRWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTKELCKLLRGTKALTEVIPLTAAAE LELAENRESLKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLAEAVQKINTESIVIWGKSPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |