Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6026 | 6026-30409 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48GMRV, I54V, V82F, L90M | L23LI, Q58E | L10I, I62V, L63P, I64L, A71T, I72V, V77I, I93L |
| >6026-30409| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTVLEEMNLPGRWKPKLIVGIGGFVKVREYD QVPLEICGHKTVGTVLIGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219E | K103KN | V35M, T39A, E40V, K43E, K101KQ, V118I, D121H, K122E, D123E, I135V, K173Q, Q207E, R211K, V245M, D250E, A272P, T286A, P294T, E298EG, G333D, Q334H, M357T, G359S, T369TA, A371V, A376T, I382IV, E399ED |
| >6026-30409| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAVLEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSIPL HEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIMLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVITLTEGAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQDHGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLAEVVQKITTESIVVWGKTPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |