Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6024 | 6024-30407 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, T215F | K219Q | Y181C | K20R, V35I, T39A, K43E, T69N, V118VI, D123E, I135L, S162SDGN, Q207E, R211K, F214L, D218E, L228H, A272P, K281KR, R284K, T286A, I293V, E297K, Q334L, M357V, T386V | L282LF |
| >6024-30407| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEEEGKISKIGPENPYNTPV FAIKKKNSNKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRFLKGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARVRGA HTNDVKQLTEAVQKIATESIVIWGKVPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33F, Q58E, G73GS | L10V, T12I, I13V, L24F, N37D, K55R, D60E, L63P, A71V, V77I, I93L |
| >6024-30407| codons 1-99 PQITLWQRPVVIVKIGGQLKEALFDTGADDTVFEEMDLPGRWKPKLIGGIGGFVRVREYE QIPIEICGHKVISTVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |