Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6023 | 6023-30403 | Italy | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82A | L24I, K43KT, F53L | L10I, I15V, Q18E, K20R, E35D, M36I, N37NK, R41K, R57K, Q61N, E65D, T74S, L89M |
| >6023-30403| codons 1-99 PQITLWQRPIVTIKVGGELREALIDTGADDTVLEDIKLPGKWTPKMIMGIGGLVKVKQYD NILIDICGHKAIGSVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | K103N | K238KT | K20R, V35T, T39N, V60I, T69E, K122P, I135V, E138G, S162C, K173A, Q174K, D177E, I178L, Q207E, R211T, D218DE, K223KT, L228H, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, E297P, R356K, M357I, G359S, T377L, I382V, Q394L, K395R, E399D |
| >6023-30403| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICNELEKEGKISKIGPENPYNTPI FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSVNNGTPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPELVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLTWGFFTPEQKHQTEPPFHWMGYELHPDTWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTPEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKIRSA HTNDVKQLTEAVQKIALESIVVWGKTPKFKLPILRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |