<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6023 6023-30403 Italy 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48M, I54V, V82A L24I, K43KT, F53L L10I, I15V, Q18E, K20R, E35D, M36I, N37NK, R41K, R57K, Q61N, E65D, T74S, L89M  
>6023-30403| codons 1-99
PQITLWQRPIVTIKVGGELREALIDTGADDTVLEDIKLPGKWTPKMIMGIGGLVKVKQYD
NILIDICGHKAIGSVLVGPTPANIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, T215F K219Q K103N K238KT K20R, V35T, T39N, V60I, T69E, K122P, I135V, E138G, S162C, K173A, Q174K, D177E, I178L, Q207E, R211T, D218DE, K223KT, L228H, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, E297P, R356K, M357I, G359S, T377L, I382V, Q394L, K395R, E399D  
>6023-30403| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICNELEKEGKISKIGPENPYNTPI
FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DPDFRKYTAFTIPSVNNGTPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPELVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLTWGFFTPEQKHQTEPPFHWMGYELHPDTWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTPEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKIRSA
HTNDVKQLTEAVQKIALESIVVWGKTPKFKLPILRETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006