Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6021 | 6021-30331 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219R | K101P, Y188L | Y318YF | V35M, T39A, K43E, E44ED, V60VI, A98S, K102Q, K104KR, V118I, K122P, D123E, I135T, E138Q, R172K, Q207E, D218E, D250E, A272P, K277KR, Q278H, T286P, A288S, I293V, E297K, K311R, M357T |
| >6021-30331| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEDGKISKIGPENPYNTPI FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLPQKRSVTVLDVGDAYFSIPL DPEFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI YQYMDDLLVGSDLEIGQHRTKIEELREHLWRWGFYTPERKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGPKSLTEVVPLTKEAE LELAENREILREPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I54L, V82T, I84V, L90M | L33F, K43T, G73S, L89V | L10V, I13V, K14R, I15V, Q18QL, K20R, E34V, E35D, M36I, N37D, I62V, L63P, I66F, A71V, P79S |
| >6021-30331| codons 1-99 PQITLWQRPVVTVRVGGLLREALLDTGADDTIFVDIDLPGRWTPKLIGGIGGFLKVRQYD QVPIEFCGHKVISTVLVGSTPTNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |