<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6021 6021-30331 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46L, I54L, V82T, I84V, L90M L33F, K43T, G73S, L89V L10V, I13V, K14R, I15V, Q18QL, K20R, E34V, E35D, M36I, N37D, I62V, L63P, I66F, A71V, P79S  
>6021-30331| codons 1-99
PQITLWQRPVVTVRVGGLLREALLDTGADDTIFVDIDLPGRWTPKLIGGIGGFLKVRQYD
QVPIEFCGHKVISTVLVGSTPTNVIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y K219R K101P, Y188L Y318YF V35M, T39A, K43E, E44ED, V60VI, A98S, K102Q, K104KR, V118I, K122P, D123E, I135T, E138Q, R172K, Q207E, D218E, D250E, A272P, K277KR, Q278H, T286P, A288S, I293V, E297K, K311R, M357T  
>6021-30331| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEDGKISKIGPENPYNTPI
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLPQKRSVTVLDVGDAYFSIPL
DPEFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLLVGSDLEIGQHRTKIEELREHLWRWGFYTPERKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGPKSLTEVVPLTKEAE
LELAENREILREPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006