<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6020 6020-30328 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I50IV, I54S, V82A L33F L10IV, I13V, G16E, K20KT, D60E, L63S, A71V, V77I, I93L  
>6020-30328| codons 1-99
PQITLWQRPVVTVKIEGQLTEALLDTGADDTVFEEMNLPGRWKPKMIVGVGGFSKVRQYE
QISIEICGHKVIGTVLIGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Q151M A62V, V75I, F116Y K103N, Y181C, G190A   K20R, S68G, V90I, K101KR, V118I, K122E, D123E, S162A, R172K, Q197K, Q207T, R211K, F214L, A272P, K277R, T286A, T296S, E297K, V317A, I329V, G333E, Q334QL, M357MR, A371AV, E399D  
>6020-30328| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FVIKRKDGTKWRKLIDFRELNKRTQDFWEIQLGIPHPAGLRKNKSVTVLDVGDAYYSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQASMTKILEPFKKQNPDIVI
CQYMDDLYVASDLEIGKHRTKIEELRTHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLSKEAE
LELAENREILKEPVHGAYYDPSKDLIAEVQKQELGQWTYQIYQEPFKNLKTGKYARRRGA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006