Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6018 | 6018-30321 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184MV, L210W, T215Y | K219R | K101E, Y181C, G190A | A98G, V108I | E28K, K32E, K43N, E44D, V60I, V118I, D123E, E138D, I178M, V189I, G196E, E203K, R211K, K223Q, D237N, A272P, K281R, T286TA, V292I, I293V, E297T, V317VA, I329V, G335S, R358K, G359S, T369TA, A371V | N54NI |
| >6018-30321| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICTELENDGKISKIGPEIPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSINNDTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI CQYVDDLYIASDLEIEQHRTKIKELRQHLWKWGFYTPDRKHQQEPPFLWMGYELHPNKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEIVPLTTEAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQGQSQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLAEVVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10FI, L33F, F53L | V11VL, G16A, E34Q, G51A, K55R, Q61N, L63P, A71L, I72IM, V77I, C95L |
| >6018-30321| codons 1-99 PQITLWQRPILTIKIAGQLKEALLDTGADDTVFQEMNLPGRWKPKIIGGIAGLVRVRQYD NIPIEICGHKLMGTVLIGPTPANIIGRNLMTQIGLTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |