<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6017 6017-30320 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, T215F K219Q K103N, Y181C, G190A   V35I, T39A, S48E, V90I, K102N, D123E, I135T, Q174R, V179I, G196E, Q207K, R211A, F214L, L228R, V245E, A272P, V292I, E297R, I329IV, G333E, G359S, T369V, A371V, A376AT, K390R, E399D, A400AT  
>6017-30320| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKIEKIGPENPYNTPV
FAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKNNKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIII
CQYMDDLYVASDLEIEQHRTKIEELRKHLLAWGLFTPDQKHQKEPPFRWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIIPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLVEVVQKITTESIVIWGKTPKFRLPIQKETWDT

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82C, L90M L10F T12S, I13M, I15V, L19Q, K20I, M36I, N37D, K55R, I62IV, L63P, H69K, A71V, I93L  
>6017-30320| codons 1-99
PQITLWQRPFVSMKVGGQQIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFVRVRQYD
QVPIEICGKKVIGTVVVGPTPCNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006