Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6017 | 6017-30320 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | K103N, Y181C, G190A | V35I, T39A, S48E, V90I, K102N, D123E, I135T, Q174R, V179I, G196E, Q207K, R211A, F214L, L228R, V245E, A272P, V292I, E297R, I329IV, G333E, G359S, T369V, A371V, A376AT, K390R, E399D, A400AT |
| >6017-30320| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKIEKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKNNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIII CQYMDDLYVASDLEIEQHRTKIEELRKHLLAWGLFTPDQKHQKEPPFRWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLVEVVQKITTESIVIWGKTPKFRLPIQKETWDT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82C, L90M | L10F | T12S, I13M, I15V, L19Q, K20I, M36I, N37D, K55R, I62IV, L63P, H69K, A71V, I93L |
| >6017-30320| codons 1-99 PQITLWQRPFVSMKVGGQQIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFVRVRQYD QVPIEICGKKVIGTVVVGPTPCNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |