Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6016 | 6016-30320 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IL, L76V, I84V, L90M | V11IL, G73S, L89V | L10I, T12TP, I13V, I15V, K20I, E35D, M36I, I62V, L63P, A71V, I72M |
| >6016-30320| codons 1-99 PQITLWQRPILPVKVGGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFLKVRQYD QVPIEICGHKVMSTVVVGPTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | V75S, K219N | K101E, Y181C, G190A | V35I, K43KDEN, E44D, R83K, V118I, K122E, D123E, I135T, S162A, H208Y, R211K, D218E, A272P, K277R, K281R, T286A, I293V, E297K, M357T, A371V, I375V, K390R |
| >6016-30320| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKISDFRELNKKTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |