Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6015 | 6015-40805 | Italy | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 72 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, Y115F, Q151M, M184V, T215CY | K70N | K101E, Y181C, G190A | V108I | E28A, S68G, K122E, D123DE, I135T, S162A, K166R, R172K, K173N, T200A, F214L, A272P, I293V, E297R, E312ED, P345Q, M357T, A360T, K366R, T386I |
| >6015-40805| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDGTNWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAFFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQASMTRILEPFKNQNPDIVI CQYVDDLYVASDLEIGQHRAKIEELRQHLLRWGLYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTREAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEQFKNLKTGKYARTRGT HTNDVRQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, I84V, L90M | K43KT, G73S, L89V | L10IV, V11L, I13V, K14R, I15V, K20I, L33V, D60DE, I62V, L63P, A71V, I72L |
| >6015-40805| codons 1-99 PQITLWQRPVLTVRVGGQLIEALLDTGADDTVVEEMNLPGRWTPKIIGGIGGFAKVRQYE QVPIEICGHKVLSTVLVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |