Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6012 | 6012-30304 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215F | N348I | L100I, K103N | P4S, K20KR, V35I, K43Q, K49KR, D123E, I135IV, K173Q, Q174H, R211K, A272P, K281R, P294T, E297R, Q334H, G335D, R356K, G359S, A371T, T377M, T386TI, K390R |
| >6012-30304| codons 1-399 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQHNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVITLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKILKTGKYAKMRSA HTNDVKQLTETVQKIAMESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10I, N37D, I62V, L63P, I64M, A71I, V77I |
| >6012-30304| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFVKVRQYD QVPMEICGHKIIGTVLIGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |