<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6009 6009-30303 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y K219N K101E, Y181C, G190S   K20R, V35VL, T39K, K43E, E44D, K49KR, A98S, V118I, K122E, E138D, G196E, E203K, Q207G, R211K, K223E, L228H, R284K, T286P, V292I, I293V, E297EAKT, D324E, A355G, G359S, V365I, A376S, K395R, E399D K65K_HN
>6009-30303| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICKELEEDGKISRIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNDTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVSSDLEIEQHRTKIKELRGHLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGPKALTEIVPLTTEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYGRMRSA
HTNDIKQLTEAVQKISTESIVIWGKTPKFKLPIQRETWDA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, L76V, V82A, L90M L10F, L33I, Q58E, G73S, L89V I13V, L19LV, K20M, M36L, L38W, I62V, L63P, A71V  
>6009-30303| codons 1-99
PQITLWQRPFVTVKIGGQVMEALLDTGADDTVIEELNWPGRWKPKMIGGIGGFVKVREYD
QVPIEICGHKVISTVVVGPTPANIIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006