Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6009 | 6009-30303 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | K101E, Y181C, G190S | K20R, V35VL, T39K, K43E, E44D, K49KR, K65K_HN, A98S, V118I, K122E, E138D, G196E, E203K, Q207G, R211K, K223E, L228H, R284K, T286P, V292I, I293V, E297EAKT, D324E, A355G, G359S, V365I, A376S, K395R, E399D |
| >6009-30303| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICKELEEDGKISRIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNDTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVSSDLEIEQHRTKIKELRGHLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGPKALTEIVPLTTEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYGRMRSA HTNDIKQLTEAVQKISTESIVIWGKTPKFKLPIQRETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L76V, V82A, L90M | L10F, L33I, Q58E, G73S, L89V | I13V, L19LV, K20M, M36L, L38W, I62V, L63P, A71V |
| >6009-30303| codons 1-99 PQITLWQRPFVTVKIGGQVMEALLDTGADDTVIEELNWPGRWKPKMIGGIGGFVKVREYD QVPIEICGHKVISTVVVGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |