Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6008 | 6008-30228 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | V11I, K43T, G73C | L10I, T12P, L19P, K20M, L63P, I64V, C67F, H69K, A71V | G16C |
| >6008-30228| codons 1-99 PQITLWQRPIIPIKICGQPMEALLDTGADDTILEEMNLPGRWTPKIIGGIGGFVKVRQYD QIPVEIFGKKVICTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215TFIS | V179AD | E6K, V35T, K122E, D123E, I135T, K166R, D177E, T200A, E203D, A272P, K277R, I293V, T296S, V317A, D324E, M357T | K104KI |
| >6008-30228| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKISVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIDI YQYMDDLYVGSDLEIGQHRAKIDELRQHLLRWGFSTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLSEEAE LELAENREILKEPVHGAYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |