<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6007 6007-30226 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84V, L90M L33F, K43T L10I, I13V, I15V, K20R, L24F, E35D, M36I, N37D, R57K, Q61N, I62V, L63A, A71V, Q92K  
>6007-30226| codons 1-99
PQITLWQRPIVTVKVGGQLREALFDTGADDTVFEDIDLPGRWTPKLIGGIGGFVKVKQYD
NVAIEICGHKVIGTVLVGPTPANVIGRNLMTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T69D, Y115F, Q151M, M184V D67G, V75L, F77L, K219Q     V118I, D123E, I135T, I142M, I178IM, T200TA, Q207K, R211T, F214L, V245Q, E248D, A272P, T286A, V292I, I293V, E297V, M357T, A376T, S379C, V381I, Q394L  
>6007-30226| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKGSDKWRKLLDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSIPL
DKEFRKYTAFTIPSTNNETPGMRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDMVI
YQYVDDLYVGSDLEIGQHRAKIEELRKHLLTWGLTTPDQKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVPLTVEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKITTECIIIWGKTPKFKLPILKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006