Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6007 | 6007-30226 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | L33F, K43T | L10I, I13V, I15V, K20R, L24F, E35D, M36I, N37D, R57K, Q61N, I62V, L63A, A71V, Q92K |
| >6007-30226| codons 1-99 PQITLWQRPIVTVKVGGQLREALFDTGADDTVFEDIDLPGRWTPKLIGGIGGFVKVKQYD NVAIEICGHKVIGTVLVGPTPANVIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, Y115F, Q151M, M184V | D67G, V75L, F77L, K219Q | V118I, D123E, I135T, I142M, I178IM, T200TA, Q207K, R211T, F214L, V245Q, E248D, A272P, T286A, V292I, I293V, E297V, M357T, A376T, S379C, V381I, Q394L, A400T |
| >6007-30226| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKGSDKWRKLLDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSIPL DKEFRKYTAFTIPSTNNETPGMRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRAKIEELRKHLLTWGLTTPDQKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVPLTVEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKITTECIIIWGKTPKFKLPILKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |