Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6006 | 6006-30221 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V | L24I | L10I, I15V, K20M, E35D, M36I, R41K, D60E, I62V, L63P, A71V, I72T |
| >6006-30221| codons 1-99 PQITLWQRPIVTIKVGGQLMEALIDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVRQYE QVPIEICGHKVTGTVLVGPTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | L100LI, K103N, Y181YC | E28EK, V35IL, E44D, V118I, K122E, A158S, K166R, T200TA, K223Q, V245M, A272P, K277R, L283I, I293V, E297K, L301I, S322T, G359S, A371V, I375V, A376S, K390R |
| >6006-30221| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALLEICTELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTRILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTKEAE IELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKVSTESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |