<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6004 6004-30219 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, T215F K219Q K103KN A98G, V108I, Y318F I2V, E6D, V35M, E44D, I50V, K64H, T69N, S117A, V118I, K122KE, D123E, I135IT, S162A, G196E, F214L, D218E, F227Y, L228H, Q242H, V245T, A272P, K277R, T286A, A288S, I293V, M357T, S379C, K385R, K390R  
>6004-30219| codons 1-399
PVSPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKDGKISKVGPENPYNTPV
FAIHKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFAIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLFTPEQKHQKEPPYHWMGYELHPDKWT
VHPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKSLTEVVPLTEEAE
LELAENREILKEPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKIATECIVIWGRTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, Q58QE, G73T R41K, K55R, I62V, L63P, I93L  
>6004-30219| codons 1-99
PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFVRVREYD
QVPIEICGHKAITTVLVGPTPVNVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006