Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6004 | 6004-30219 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, Q58QE, G73T | R41K, K55R, I62V, L63P, I93L |
| >6004-30219| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFVRVREYD QVPIEICGHKAITTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | K219Q | K103KN | A98G, V108I, Y318F | I2V, E6D, V35M, E44D, I50V, K64H, T69N, S117A, V118I, K122KE, D123E, I135IT, S162A, G196E, F214L, D218E, F227Y, L228H, Q242H, V245T, A272P, K277R, T286A, A288S, I293V, M357T, S379C, K385R, K390R |
| >6004-30219| codons 1-399 PVSPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKDGKISKVGPENPYNTPV FAIHKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFAIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLFTPEQKHQKEPPYHWMGYELHPDKWT VHPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKSLTEVVPLTEEAE LELAENREILKEPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATECIVIWGRTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |