Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6003 | 6003-30218 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69G_SG, T215Y | V35I, K64KR, A98S, K122KE, D123DE, I178IM, R211K, L228H, V245E, K249KQ, A272P, K281R, T286A, E297K, I329V, Q334D, M357R, R358K, A371V, S379G, K390R, K395R, E396D, E399D |
| >6003-30218| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIRKKDSGKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEQDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGDGQWTYQIYQEPFKNLKTGKYARRKGA HTNDVKQLTEVVQKIATEGIVIWGKTPKFRLPIQRDTWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L33F, G73S | L10I, E34EQ, E35D, M36I, K43S, K55R, I62V, L63P, C67F, H69K, A71V | C95CFGV |
| >6003-30218| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQDINLPGRWSPKIIGGVGGFVRVRQYD QVPIEIFGKKVISTVLVGPTPANIIGRNLMTQIGVTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |