Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6002 | 6002-30218 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | L10F, L33F | G16GA, R41K, D60E, Q61DN, L63P, A71V, I93L |
| >6002-30218| codons 1-99 PQITLWQRPFVTIKIAGQLKEALLDTGADDTVFEEMNLPGKWKPKLIGGIGGFVKVRQYE NIPIEICGHKVIGTVLVGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K20R, V35L, K43Q, E44D, K49R, V118I, K122E, S162N, E169D, E203K, Q207E, H208Y, R211K, K223E, A272P, L283I, I293V, D324E, G333E, R356K, G359S, A360S, K366R, A371V, A376S, T377L, T386I |
| >6002-30218| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELEQDGKISRIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKMRSS HTNDVRQLTEVVQKISLESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |