Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6001 | 6001-30218 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70KE, Q151M | A62V, V75I, F116Y | G190Q | V179D | V21VI, V35T, S68X, K122E, I135V, T139TA, I202V, R211K, A272P, L283I, E297R, V317A, M357T, I375V, T386I |
| >6001-30218| codons 1-399 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FVIKKKDXTEWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL DEDFRKYTAFTIPSVNNEAPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIDI YQYMDDLYVQSDLEIGQHRTKVEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTREAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKVATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV, L90M | L33F | L10LI, T12TA, I13V, K20KR, M36I, N37D, I62V, L63P, H69K, A71AV |
| >6001-30218| codons 1-99 PQITLWQRPIVAVKIGGQLREALLDTGADDTVFEEIDLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGKKVIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |