<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5096 5096-30901 Greece 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M K43KT, T74P L10V, I13A, K20IM, E21K, A22V, M36I, R41RK, K55R, Q61N, L63P, I64V, H69K, L89M, I93L  
>5096-30901| codons 1-99
PQITLWQRPVVTAKIGGQLMKVLLDTGADDTVLEEINLPGKWTPKIIGGIGGFVRVRQYD
NIPVEICGKKAIGPVLVGPTPANIIGRNMMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, Y115F, M184V, T215Y       V21I, V35T, E36A, T39E, S68SG, K122E, D123NS, A158S, K173AT, Q174K, T200A, E203D, Q207D, E224D, L228LH, V245Q, K249Q, A272P, L283I, T286A, E291D, V292VI, I293V, K311R, Q334H, G335D, R356K, M357R, R358K, G359A, A371V, T377TI, K390R  
>5096-30901| codons 1-400
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTAICEEMEKEGKISKIGPENPYNTPV
FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRTKNPDIVI
YQYVDDLYVGSDLEIGQHRAKIDELRDHLLRWGFYTPDKKHQKDPPFHWMGYELHPDKWT
VQPIQLPEQDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGAKALTDIVPLTEEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRKAA
HTNDVKQLTEVVQKIAIESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006