Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5096 | 5096-30901 | Greece | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | K43KT, T74P | L10V, I13A, K20IM, E21K, A22V, M36I, R41RK, K55R, Q61N, L63P, I64V, H69K, L89M, I93L |
| >5096-30901| codons 1-99 PQITLWQRPVVTAKIGGQLMKVLLDTGADDTVLEEINLPGKWTPKIIGGIGGFVRVRQYD NIPVEICGKKAIGPVLVGPTPANIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, Y115F, M184V, T215Y | V21I, V35T, E36A, T39E, S68SG, K122E, D123NS, A158S, K173AT, Q174K, T200A, E203D, Q207D, E224D, L228LH, V245Q, K249Q, A272P, L283I, T286A, E291D, V292VI, I293V, K311R, Q334H, G335D, R356K, M357R, R358K, G359A, A371V, T377TI, K390R |
| >5096-30901| codons 1-400 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTAICEEMEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRTKNPDIVI YQYVDDLYVGSDLEIGQHRAKIDELRDHLLRWGFYTPDKKHQKDPPFHWMGYELHPDKWT VQPIQLPEQDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGAKALTDIVPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRKAA HTNDVKQLTEVVQKIAIESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |