Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5091 | 5091-30901 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I84V, L90M | Q58E | L10I, E35D, N37NT, L63P, I64V, V77I, I93L | D60NT |
| >5091-30901| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMTLPGRWKPKLIGGIGGFIKVREYT QIPVEICGHKAIGTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, M184V, L210W, T215Y | K101P, K103S | K11KR, K20R, D123E, I142V, T200E, E203K, Q207E, R211K, A272P, T286P, I293V, E297R, I329IV, G333D, G335S, K366R, A371V, A376T, S379SC |
| >5091-30901| codons 1-399 PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLPKSKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHREKIKELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGPKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQDQSQWTYQIYQEPFKNLKTGKYARMRGA HTNDVRQLTEVVQKITTECIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |