Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5080 | 5080-30903 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S | L24I, Q58E | L10I, K20M, E35N, M36V, N37D, D60E, Q61QE, I62V, L63P, I64V, I85V |
| >5080-30903| codons 1-99 PQITLWQRPIVTIKIGGQLMEALIDTGADDTVLENVDLPGRWKPKMIVGIGGFVKVREYE EVPVEICGHKAIGTVLVGPTPSNIVGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | V75S, K219N | K103N, Y181C | V108I, K238T | K11KR, K20R, V35VL, T39A, K43E, E44A, V60I, R83K, V118I, K122E, S162A, G196E, E203K, Q207E, R211K, K223Q, L228H, Q242H, A272P, K275R, I293V, P294Q, G333E, G359S, T369A, A371V, A376S, S379C, K390R |
| >5080-30903| codons 1-399 PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALLEICAELEEAGKISKIGPENPYNTPI FAIKKKNSTKWRKISDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRTKIKELREHLWKWGFYTPDNKHQQEPPFHWMGYELHPDTWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEVVQLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLAEVVQKISTECIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |