<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5076 5076-30807 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82F, L90M G73C L10I, I13M, K20I, E35G, M36I, D60E, I62V, L63P, I64V, I72L, V77VI, I93L  
>5076-30807| codons 1-99
PQITLWQRPIVTMKIGGQLIEALLDTGADDTVLEGINLPGRWKPKIIGGIGGFVKVRQYE
QVPVEICGHKALCTVLIGPTPFNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, T215Y V75A, K219E K103N V108I K43Q, V60I, T69N, V118I, K122E, D123E, I135T, E169D, D177E, G196E, E203K, H208Y, L210Y, R211K, D218E, L228H, Q242H, I257IL, A272S, A288S, I293V, E297A, P313Q, G335S, K350R, R356K, R358K, G359S, A371V, A376S, S379C, K390R, A400AT  
>5076-30807| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPI
FAIKKKNSNRWRKIADFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIVI
YQYVDDLYVGSDLEIEQHRTKIKELRQYLYKWGFYTPEEKHQKEPPFHWMGYELHPDKWT
VHPIVLPEKDSWTVNDLQKLVGKLNWASQIYSGIKVKQLCKLLRGTKSLTEVVPLTAEAE
LELAENREILKEQVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKNLRTGKYAKMKSA
HTNDVKQLTEVVQKISTECIVIWGKTPKFRLPIQKETWET

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006