Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5076 | 5076-30807 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, L90M | G73C | L10I, I13M, K20I, E35G, M36I, D60E, I62V, L63P, I64V, I72L, V77VI, I93L |
| >5076-30807| codons 1-99 PQITLWQRPIVTMKIGGQLIEALLDTGADDTVLEGINLPGRWKPKIIGGIGGFVKVRQYE QVPVEICGHKALCTVLIGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215Y | V75A, K219E | K103N | V108I | K43Q, V60I, T69N, V118I, K122E, D123E, I135T, E169D, D177E, G196E, E203K, H208Y, L210Y, R211K, D218E, L228H, Q242H, I257IL, A272S, A288S, I293V, E297A, P313Q, G335S, K350R, R356K, R358K, G359S, A371V, A376S, S379C, K390R, A400AT |
| >5076-30807| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPI FAIKKKNSNRWRKIADFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRTKIKELRQYLYKWGFYTPEEKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDLQKLVGKLNWASQIYSGIKVKQLCKLLRGTKSLTEVVPLTAEAE LELAENREILKEQVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKNLRTGKYAKMKSA HTNDVKQLTEVVQKISTECIVIWGKTPKFRLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |