<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5072 5072-30807 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215CFGV K219N G190Q   K20R, V35I, K43Q, E44D, K102KR, V118I, K122E, I135T, D177E, V179I, G196E, T200A, E203D, H208Y, R211K, I244IV, V245Q, A272P, I293V, E297T, I329V, R356K, M357MIL, G359S, A376CS, S379C, T386I, K390R  
>5072-30807| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII
YQYVDDLYVQSDLEIEQHRAKIDELRQYLWKWGFVTPDNKHQKEPPFLWMGYELHPDKWT
VQPVQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTTEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYAKLRSA
HTNDVKQLTEAVQKISTECIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, V82A, L90M L10F, L33I, Q58E, L89V I13V, K20M, E35N, M36I, N37D, K55R, D60E, Q61E, I62V, L63P, A71T, I72T, Q92QR  
>5072-30807| codons 1-99
PQITLWQRPFVTVKIGGQLMEALLDTGADDTVIENIDLPGRWKPKIVGGIGGFVRVREYE
EVPIEICGHKTTGTVLVGPTPANIIGRNVMTRIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006