Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5072 | 5072-30807 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82A, L90M | L10F, L33I, Q58E, L89V | I13V, K20M, E35N, M36I, N37D, K55R, D60E, Q61E, I62V, L63P, A71T, I72T, Q92QR |
| >5072-30807| codons 1-99 PQITLWQRPFVTVKIGGQLMEALLDTGADDTVIENIDLPGRWKPKIVGGIGGFVRVREYE EVPIEICGHKTTGTVLVGPTPANIIGRNVMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215CFGV | K219N | G190Q | K20R, V35I, K43Q, E44D, K102KR, V118I, K122E, I135T, D177E, V179I, G196E, T200A, E203D, H208Y, R211K, I244IV, V245Q, A272P, I293V, E297T, I329V, R356K, M357MIL, G359S, A376CS, S379C, T386I, K390R |
| >5072-30807| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII YQYVDDLYVQSDLEIEQHRAKIDELRQYLWKWGFVTPDNKHQKEPPFLWMGYELHPDKWT VQPVQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTTEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYAKLRSA HTNDVKQLTEAVQKISTECIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |