Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5071 | 5071-30807 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82AT, L90M | V11VI, G73S | L10I, I13L, K20R, L24M, E35D, M36I, N37D, K55R, I62V, L63P, C67F, H69K, A71V, I72FL |
| >5071-30807| codons 1-99 PQITLWQRPIITLKIGGQLREALMDTGADDTVLEDIDLPGRWKPKIIGGIGGFVRVRQYD QVPIEIFGKKVLSTVLVGPTPTNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70G, L74V, V75M, M184V, T215Y | D67G | L100I, K103N | K20R, T39TA, I50IT, S68N, K102KN, K122E, D123E, I135T, S162SN, I178L, G196E, T200TA, E224D, A272P, K281R, I293V, P294T, E297R, V317A, F346FY, M357T, T369TA, E370D, A376T, T377L, T386A | V381VIM |
| >5071-30807| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAEMEKEGKISKTGPENPYNTPV FAIKKKGNTGWRKVMDFRELNKRTQDFWEVQLGIPHPAGIKNNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDLVI YQYVDDLYVGSDLEIEQHRAKIEELRQHLLRWGFYTPDKKHQKDPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVTLTREAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPYKNLKTGKYARTRGA HTNDVKQLADAVQKITLESIMIWGKAPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |