Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5063 | 5063-30610 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, T39S, K102Q, K103R, K122E, I135T, I142V, E204Q, Q207E, R211K, F214L, V245M, Q278H, K281R, E291K, I293V, E297A, V317A, Q334H, F346Y, T377M |
| >5063-30610| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICSEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQRKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEQLREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCRLLRGTKALTKVVPLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGHGQWTYQIYQEPYKNLKTGKYARMRGA HTNDVKQLTEAVQKIAMESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12K, I13V, E35D, R41K, R57K, D60E, L63P, I64V |
| >5063-30610| codons 1-99 PQITLWQRPLVKVKIGGQLKEALLDTGADDTVLEDMNLPGKWKPKMIGGIGGFIKVKQYE QIPVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |