Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5062 | 5062-30603 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, Y115F, M184V, T215Y | K219Q | Y181C | V35I, T39A, E44D, S48ST, K122E, D123E, T139L, S162D, G196E, H208Y, R211RK, F214FL, D218E, L228H, V292I, I293V, E297P, M357R, R358RK, K366R, T369A, A376S, K390R, Q394N, E399D |
| >5062-30603| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKITKIGPENPYNTPV FAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL DEEFRKYTAFTIPSINNELPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIEQHRTKIEELRQYLLKWGLYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTPEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARRKGA HTNDVRQLAEAVQKISTESIVIWGKTPKFRLPINKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L33I, G73C | L10I, I13V, Q18H, K20T, E34EQ, E35D, M36I, K55R, D60E, Q61D, I62V, L63P, I64V, I66L, I72K, P79A, I93L |
| >5062-30603| codons 1-99 PQITLWQRPIVTVKIGGHLTEALLDTGADDTVIQDINLPGRWKPKIIGGIGGFVRVRQYE DVPVELCGHKAKCTVLVGATPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |