<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5062 5062-30603 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L33I, G73C L10I, I13V, Q18H, K20T, E34EQ, E35D, M36I, K55R, D60E, Q61D, I62V, L63P, I64V, I66L, I72K, P79A, I93L  
>5062-30603| codons 1-99
PQITLWQRPIVTVKIGGHLTEALLDTGADDTVIQDINLPGRWKPKIIGGIGGFVRVRQYE
DVPVELCGHKAKCTVLVGATPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, V75T, Y115F, M184V, T215Y K219Q Y181C   V35I, T39A, E44D, S48ST, K122E, D123E, T139L, S162D, G196E, H208Y, R211RK, F214FL, D218E, L228H, V292I, I293V, E297P, M357R, R358RK, K366R, T369A, A376S, K390R, Q394N, E399D  
>5062-30603| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKITKIGPENPYNTPV
FAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL
DEEFRKYTAFTIPSINNELPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI
CQYVDDLYVGSDLEIEQHRTKIEELRQYLLKWGLYTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTPEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARRKGA
HTNDVRQLAEAVQKISTESIVIWGKTPKFRLPINKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006