Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5058 | 5058-30930 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V | T215C | V106A, G190A | F227L | K43Q, E44D, K64R, K122E, G196E, H208Y, L210F, R211K, D218E, I293V, E297A, Q334E, Y342F, G359A, A371V, K390R |
| >5058-30930| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIRKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIEQHRTKIEELRQYLFKWGFCTPEKKHQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIFQEPFKNLKTGKYARMRAA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L10LF, Q58E | E35D, M36I, D60E, I62V, L63P, I64V, Q92R, I93L, C95F |
| >5058-30930| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVREYE QVPVEICGHKAIGTVLVGPTPVNIIGRNLMTRLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |