Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5053 | 5053-30516 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, V82VA, I84V | L10F, L24I, L33F, F53L, T74AP | I13V, E34Q, M36L, D60E, I62V, L63P, I64V |
| >5053-30516| codons 1-99 PQITLWQRPFVTVKIGGQLKEALIDTGADDTVFQELNLPGRWKPKIIGGIGGLMKVRQYE QVPVEICGHKAIGPVLVGPTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74I, V75T, M184V, L210W, T215Y | K219E | L100I, K103S | K20R, V35I, T39A, E44D, V118I, K122E, D123E, S162D, D177G, G196E, T200A, E203K, H208Y, R211K, D218E, K223Q, L228H, Q242H, A272P, K277R, L283I, I293V, E297A, Y342F, G359S, A371V, A376S, S379C, K390R |
| >5053-30516| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKITDFRELNKRTQDFWEVQLGIPHPAGIKKSKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPGIVI YQYVDDLYVGSDLEIEQHRAKIKELRQYLWKWGFYTPEEKHQQEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIFQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKISTECIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |