Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5052 | 5052-30515 | Greece | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | Y188L | P4S, K20R, V35T, T39R, K43E, E44D, V60I, K64H, L109I, V118I, I135V, T139V, S162D, K166R, K173A, D177E, Q207E, R211K, D218E, E224ED, V245Q, E248D, D250E, S251N, A272P, K277R, L283I, A288T, I293V, E297K, G333E, Q334H, G335NS, G359S, A371V, T377M, K390R |
| >5052-30515| codons 1-400 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICRELEEDGKISKIGPENPYNTPI FAIHKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVIDVGDAYFSIPL DKDFRKYTAFTIPSVNNEVPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRAQNPEIVI YQYMDDLLVGSDLEIGQHRTKIEELREHLWKWGFYTPEKKHQKDPPFLWMGYELHPDKWT VQPIQLPDKENWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKTLTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHSQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIAMESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, G48M, I54V, V82A, L90M | F53L, L89IV | T4S, L10IV, I13V, K14R, G17DE, K20I, L33L_L, M36V, R41K, L63P, H69K, K70R, A71T, T74S, Q92K |
| >5052-30515| codons 1-99 PQISLWQRPVVTVRIGEQLIEALLDTGADDTVLEEVNLPGKWKPKIIMGIGGLVKVRQYD QIPIEICGKRTIGSVLVGPTPANIIGRNVMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |