<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5052 5052-30515 Greece 2003 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, G48M, I54V, V82A, L90M F53L, L89IV T4S, L10IV, I13V, K14R, G17DE, K20I, L33L_L, M36V, R41K, L63P, H69K, K70R, A71T, T74S, Q92K  
>5052-30515| codons 1-99
PQISLWQRPVVTVRIGEQLIEALLDTGADDTVLEEVNLPGKWKPKIIMGIGGLVKVRQYD
QIPIEICGKRTIGSVLVGPTPANIIGRNVMTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, V75M, L210W, T215Y   Y188L   P4S, K20R, V35T, T39R, K43E, E44D, V60I, K64H, L109I, V118I, I135V, T139V, S162D, K166R, K173A, D177E, Q207E, R211K, D218E, E224ED, V245Q, E248D, D250E, S251N, A272P, K277R, L283I, A288T, I293V, E297K, G333E, Q334H, G335NS, G359S, A371V, T377M, K390R  
>5052-30515| codons 1-400
PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICRELEEDGKISKIGPENPYNTPI
FAIHKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVIDVGDAYFSIPL
DKDFRKYTAFTIPSVNNEVPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRAQNPEIVI
YQYMDDLLVGSDLEIGQHRTKIEELREHLWKWGFYTPEKKHQKDPPFLWMGYELHPDKWT
VQPIQLPDKENWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKTLTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHSQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKIAMESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006