Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5048 | 5048-30515 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | F53L, Q58E | L10I, K20R, E35D, M36I, N37A, I62V, L63P, A71V, V77I, I93L |
| >5048-30515| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIALPGRWKPKMIGGIGGLVKVREYD QVPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69G_SG, L210W, T215Y | A62V | K101E, Y181I, G190A | A98G, V108I | K43E, K64R, W88C, K122E, E138A, K166R, T200A, I202V, E203K, L228H, A272P, K277R, T286A, E297K, A376V, T386I |
| >5048-30515| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEEEGKISKIGPENPYNTPV FVIRKKDSGKWRKLVDFRELNKRTQDFCEVQLGIPHPGGLEKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI IQYMDDLYVASDLEIGQHRAKVKELRQHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIVTESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |