<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5046 5046-30424 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82S L24I, T74P L10I, T12P, K14R, K20M, R41K, Q61N, I62V, L63PQ, I64V, E65D, A71V, I72V, V77I, I93L  
>5046-30424| codons 1-99
PQITLWQRPIVPIRIGGQLMEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFVKVRQYD
NVQVDICGHKVVGPVLIGPTPSNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, T215F K219Q Y181C, G190A V179E P9PT, K20R, T27S, V35T, V60I, K101Q, K103R, V118I, D123E, I135T, E138EG, S162D, I178L, Q197L, Q207E, F214L, L228H, A272P, K275R, V292VI, I293V, E297K, V317A, D324E, Q334H, T338S, R356K, R358K, A360V, Q367E, T369V, E370G, Q373H, V381I  
>5046-30424| codons 1-400
PISPIETVTVKLKPGMDGPRVKQWPLSEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKRKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNGTPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDLEI
CQYMDDLYVASDLEIGLHRTKIEELREHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEIVPLTKEAE
LELAENREILKEPVHGAYYDPSKELIAEIQKQGHGQWSYQIYQEPFKNLKTGKYAKMKGV
HTNDVKELVGAVHKIATESIIIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006