Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5046 | 5046-30424 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82S | L24I, T74P | L10I, T12P, K14R, K20M, R41K, Q61N, I62V, L63PQ, I64V, E65D, A71V, I72V, V77I, I93L |
| >5046-30424| codons 1-99 PQITLWQRPIVPIRIGGQLMEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFVKVRQYD NVQVDICGHKVVGPVLIGPTPSNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | Y181C, G190A | V179E | P9PT, K20R, T27S, V35T, V60I, K101Q, K103R, V118I, D123E, I135T, E138EG, S162D, I178L, Q197L, Q207E, F214L, L228H, A272P, K275R, V292VI, I293V, E297K, V317A, D324E, Q334H, T338S, R356K, R358K, A360V, Q367E, T369V, E370G, Q373H, V381I |
| >5046-30424| codons 1-400 PISPIETVTVKLKPGMDGPRVKQWPLSEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKRKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNGTPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDLEI CQYMDDLYVASDLEIGLHRTKIEELREHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEIVPLTKEAE LELAENREILKEPVHGAYYDPSKELIAEIQKQGHGQWSYQIYQEPFKNLKTGKYAKMKGV HTNDVKELVGAVHKIATESIIIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |