<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5044 5044-30423 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L74LI, V75VAIT, T215F K219Q K103N, Y181C A98G, V179VF V60VI, K101KR, K122E, D123DE, I135T, T200I, I202IV, R211K, D218E, L228H, K238KR, A272P, K281R, A371V, I375IV, K388KR, A400AT  
>5044-30423| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKITDFRELNKRTQDFWEVQLGIPHPGGLRKNKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIFI
CQYMDDLYVGSDLEIGQHRIKVEELRQHLLKWGFFTPEQKHQKEPPFHWMGYELHPDRWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEVVQKVATESIVIWGKTPRFKLPIQKETWET

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I50IV, I54AV, V82A, L90M L33F, K43T L10I, I13V, K20R, E35D, M36I, N37D, I62V, I64IV, I66F, A71V, Q92QK P81PL
>5044-30423| codons 1-99
PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDIDLPGRWTPKMIGGVGGFVKVRQYD
QVLVEFCGHKVIGTVLVGPTLANIIGRNLMTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006