Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2105 | CA7763 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 69 |
| 2 | D4T | 22 |
| 3 | AZT | 11 |
| 4 | AZT+ 3TC | 12 |
| 5 | AZT+ 3TC+ IDV | 50 |
| 6 | DDI+ D4T+ NFV | 58 |
| 7 | D4T+ DLV+ NFV | 19 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, N88S | T12S, L19I, R57K, L63P, V77I, I93L |
| >CA7763| codons 1-99 PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVKQYD QIPIEICGHKAIGTVLIGPTPVNIIGRSLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215F | K103NT | V35L, T39K, K43E, I135L, S162C, R211E |
| >CA7762| codons 1-258 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICKELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLEWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQ |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |