Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5036 | 5036-30723 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| Q58E | L10I, E35DN, N37D, P39PS, R41K, R57RK, D60E, I62V, L63A, A71T, P79PS |
| >5036-30723| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLENMDLSGKWKPKMIGGIGGFIKVKEYE QVAIEICGHKTIGTVLVGSTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35VI, D123E, I135IV, D177E, I178M, T200A, A272P, K281KR, P294PS, I326T, Q334L, M357T, T369A, Q373H, K374R, T377L |
| >5036-30723| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVISLTEEAE LELAENREILKEPVHGVYYDPSKDLTAEIQKQGLGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLAEAVHRIALESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |