Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5034 | 5034-30421 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, T215Y | K219R, N348I | K103N | A98AG, V108I | K20R, E28K, K32E, V35I, T39K, K43E, E44D, K64H, K102KQ, V118I, D123N, K166R, D177E, V189VI, T200E, E203K, R211K, D218E, K223Q, L228LH, V245M, A272P, E297A, Y342F, K350KR, R358K, G359S, T369A, A376V, T377M, S379SC, T386TA, K390R | L210T |
| >5034-30421| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALIEICKELEEDGKISKIGPENPYNTPV FAIHKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKQNKSVTILDVGDAYFSIPL DKNFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI YQYVDDLYIGSDLEIGQHREKIKELRQHLTKWGFYTPERKHQQEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIFQEPFKILRTGKYARMKSA HTNDVKQLAEAVQKIVMECIVIWGKAPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, L76LV, I84V, L90M | L10F, G73S, L89LV | T12S, I15V, G16A, L19I, K20IV, K55KR, I62V, L63P, A71AT, I72L |
| >5034-30421| codons 1-99 PQITLWQRPFVSIKVAGQIVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVRVRQYD QVPIEICGHKTLSTVVVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |