<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5034 5034-30421 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, T215Y K219R, N348I K103N A98AG, V108I K20R, E28K, K32E, V35I, T39K, K43E, E44D, K64H, K102KQ, V118I, D123N, K166R, D177E, V189VI, T200E, E203K, R211K, D218E, K223Q, L228LH, V245M, A272P, E297A, Y342F, K350KR, R358K, G359S, T369A, A376V, T377M, S379SC, T386TA, K390R L210T
>5034-30421| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALIEICKELEEDGKISKIGPENPYNTPV
FAIHKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKQNKSVTILDVGDAYFSIPL
DKNFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI
YQYVDDLYIGSDLEIGQHREKIKELRQHLTKWGFYTPERKHQQEPPFHWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIFQEPFKILRTGKYARMKSA
HTNDVKQLAEAVQKIVMECIVIWGKAPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54IV, L76LV, I84V, L90M L10F, G73S, L89LV T12S, I15V, G16A, L19I, K20IV, K55KR, I62V, L63P, A71AT, I72L  
>5034-30421| codons 1-99
PQITLWQRPFVSIKVAGQIVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVRVRQYD
QVPIEICGHKTLSTVVVGPTPVNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006