<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5033 5033-30421 Greece 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, Q151M A62V, V75I, F116Y, K219Q K103N, Y181C, G190A   K20R, V35M, D121C, K122E, S162D, K166R, D177E, I178V, F214L, L228H, V245M, A272P, K277R, I293V, E297K, G333E, Q334QH, R356K, T369V, A376V, T386P, K390R A360N
>5033-30421| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV
FVIKKKNSDKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYYSVPL
CEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQDSMTRILEPFRKQNPEVVI
CQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTPDQKHQKEPPFHWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKMRGN
HTNDVKQLVEAVQKIVTESIVIWGKPPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82T, I84V   L10I, I15V, L19I, K20R, M36I, R41K, I62V, L63S, I64IM, A71V, I72IV  
>5033-30421| codons 1-99
PQITLWQRPIVTIKVGGQIREALLDTGADDTVLEEINLPGKWKPKIIGGIGGFVKVRQYD
QVSMEICGHKVVGTVVVGPTPTNVIGRNLLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006