Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5033 | 5033-30421 | Greece | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82T, I84V | L10I, I15V, L19I, K20R, M36I, R41K, I62V, L63S, I64IM, A71V, I72IV |
| >5033-30421| codons 1-99 PQITLWQRPIVTIKVGGQIREALLDTGADDTVLEEINLPGKWKPKIIGGIGGFVKVRQYD QVSMEICGHKVVGTVVVGPTPTNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, Q151M | A62V, V75I, F116Y, K219Q | K103N, Y181C, G190A | K20R, V35M, D121C, K122E, S162D, K166R, D177E, I178V, F214L, L228H, V245M, A272P, K277R, I293V, E297K, G333E, Q334QH, R356K, A360N, T369V, A376V, T386P, K390R |
| >5033-30421| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FVIKKKNSDKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYYSVPL CEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQDSMTRILEPFRKQNPEVVI CQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTPDQKHQKEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKMRGN HTNDVKQLVEAVQKIVTESIVIWGKPPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |