Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5032 | 5032-30421 | Greece | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | E28K, K32E, V35T, T39LP, E40ED, V60I, S68G, K122E, D123S, I135T, K173AS, Q174K, D177DE, V179I, T200A, Q207A, R211S, V245Q, D250E, T286A, E291D, I293V, P294T, E312D, G335D, M357R, G359S, T369V, A371V, I375V, A376V, T377M |
| >5032-30421| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALTEICPDLEKEGKISKIGPENPYNTPI FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII YQYVDDLYVGSDLEIGQHRAKIEELRAHLLSWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVTLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARRRSA HTNDVKQLVEVVQKVVMESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | L10F, L33I, L89V | I13V, E35D, M36I, R41K, R57K, I62IV, L63LP, H69K |
| >5032-30421| codons 1-99 PQITLWQRPFVTVKIGGQLKEALLDTGADDTVIEDINLPGKWKPKMIGGIGGFVKVKQYD QVPIEICGKKAIGTVLVGPTPVNIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |