<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5032 5032-30421 Greece 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, T215Y       E28K, K32E, V35T, T39LP, E40ED, V60I, S68G, K122E, D123S, I135T, K173AS, Q174K, D177DE, V179I, T200A, Q207A, R211S, V245Q, D250E, T286A, E291D, I293V, P294T, E312D, G335D, M357R, G359S, T369V, A371V, I375V, A376V, T377M  
>5032-30421| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALTEICPDLEKEGKISKIGPENPYNTPI
FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII
YQYVDDLYVGSDLEIGQHRAKIEELRAHLLSWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVTLTEEAE
LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARRRSA
HTNDVKQLVEVVQKVVMESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, L90M L10F, L33I, L89V I13V, E35D, M36I, R41K, R57K, I62IV, L63LP, H69K  
>5032-30421| codons 1-99
PQITLWQRPFVTVKIGGQLKEALLDTGADDTVIEDINLPGKWKPKMIGGIGGFVKVKQYD
QVPIEICGKKAIGTVLVGPTPVNIIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006