Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-5031 | 5031-30421 | Greece | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219E | Y181C, G190A | K20R, T27S, V35T, V60I, T69N, K122Q, I135T, K173A, Q174K, V179I, Q207A, L228H, V245K, D250E, K281R, T286A, E291D, I293V, P294T, E312D, G335D, M357K, G359S, T369V, A371V, I375V, T377M, K390R |
| >5031-30421| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DQDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPDIII CQYVDDLYVASDLEIGQHRTKIEELRAHLLRWGFFTPDEKHQKEPPFHWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDVVTLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA HTNDVKQLVEVVQKVAMESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | G73S | I13V, I15V, K20I, E35D, M36I, Q61H, L63D, H69K, A71V, L89T |
| >5031-30421| codons 1-99 PQITLWQRPLVTVKVGGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD HIDIEICGKKVISTVLVGPTPANIIGRNTLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |