<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-5031 5031-30421 Greece 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V, T215F K219E Y181C, G190A   K20R, T27S, V35T, V60I, T69N, K122Q, I135T, K173A, Q174K, V179I, Q207A, L228H, V245K, D250E, K281R, T286A, E291D, I293V, P294T, E312D, G335D, M357K, G359S, T369V, A371V, I375V, T377M, K390R  
>5031-30421| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DQDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPDIII
CQYVDDLYVASDLEIGQHRTKIEELRAHLLRWGFFTPDEKHQKEPPFHWMGYELHPDKWT
VQPIKLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDVVTLTEEAE
LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA
HTNDVKQLVEVVQKVAMESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A G73S I13V, I15V, K20I, E35D, M36I, Q61H, L63D, H69K, A71V, L89T  
>5031-30421| codons 1-99
PQITLWQRPLVTVKVGGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD
HIDIEICGKKVISTVLVGPTPANIIGRNTLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006